Alpha-ketoglutarate (AKG) has been shown to extend lifespan in various model organisms such as C. elegans, fruit flies and mice ². AKG works beneficially on various aging mechanisms such as epigenetic and mitochondrial dysfunction ².
Epigenetic regulation is the intricate molecular machinery surrounding the DNA that decides which genes are switched on or off. During aging, the epigenome becomes more and more dysregulated. Alpha-ketoglutarate has beneficial impacts on the epigenome and works synergistically with vitamin C to properly regulate it ¹.
Mitochondrial dysfunction is a hallmark of aging and age-related diseases. Recent studies have unveiled a complex intersection among environmental factors, epigenetic signals, and mitochondrial metabolism, ultimately leading to alterations of vascular phenotype and increased cardiovascular risk ²⁵.
Evidence suggests that mitochondrial dysfunction may often precede other pathological signs in these disorders, further modulated by genetics, environment, and lifestyle ³.
Epigenetic regulators with neurotoxic characteristics upregulate mitochondrial dysfunction (imbalance mitochondrial fission and fusion reaction and reduced mitochondrial function) and oxidative stress to trigger neuronal injury, apoptosis, and disrupt autophagy due to α‐synuclein protein inclusions, the hallmark of Parkinsonism ⁵.
Calcium alpha-ketoglutarate (Ca-AKG) promotes cellular energy and restores vitality by revitalizing cellular energy levels ³. It also helps reduce age-related inflammation ³. In addition, Ca-AKG functions as an antioxidant and helps regulate nitrogen and ammonia balance ⁴.
Calcium alpha-ketoglutarate enables the alpha-ketoglutarate to be broken down slower and has the most science behind it to extend lifespan ¹.
In conclusion, calcium alpha-ketoglutarate has several health benefits such as promoting cellular energy, reducing age-related inflammation, regulating nitrogen and ammonia balance. It has also been shown to extend lifespan in mice.
Alpha-ketoglutarate works beneficially on various aging mechanisms such as epigenetic regulation and mitochondrial dysfunction. However, more research is needed to determine its effects on humans.
(1) Epigenetic Control of Mitochondrial Function in the Vasculature. https://www.frontiersin.org/articles/10.3389/fcvm.2020.00028/full.
(2) The Anti-Aging & Longevity Effects of Alpha-Ketoglutarate – NOVOS. https://novoslabs.com/novos-anti-aging-longevity-supplement/alpha-ketoglutarate-anti-aging-supplement-longevity/.
(3) The epigenetic mechanisms involved in mitochondrial dysfunction …. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9048811/.
(4) Recent advances and new perspectives in mitochondrial dysfunction – Nature. https://www.nature.com/articles/s41598-023-34624-8.
(5) Epigenetic codes of mitochondrial homeostasis | Nature Aging. https://www.nature.com/articles/s43587-021-00034-6.
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